Rapid detection can curtail disease outbreaks
www.chinaview.cn 2007-01-04 08:35:02

    LOS ANGELES, Jan. 3 (Xinhua) -- Rapid detection combined with aggressive education can dramatically curtail outbreaks of emerging infectious disease such as severe acute respiratory syndrome (SARS), a study said.

    The study, conducted by researchers at the University of Georgia, said the size of an outbreak could be affected if information about a disease is gathered at high speed and quickly disseminated to the public.

    In the study, John Drake, assistant professor in the UG Institute of Ecology, used a mathematical model to evaluate how an outbreak could be curtailed.

    The model found that in the 2003 SARS outbreak in Singapore, doubling the rate at which infected people removed themselves from the larger population by quarantining themselves or seeking treatment would have cut the total number of infected people from 238 to 116. If infected individuals had removed themselves at half the actual rate, the number of cases would have ballooned to nearly 800.

    "Infectious diseases are like weeds," Drake said. "They grow multiplicatively - two infected people, four infected, eight and so forth. So that means you have exponential returns in your ability to control the outbreak the earlier you catch it."

    Drake said that with modifications to account for differences in factors such as transmission rate, the model can be applied to other emerging infectious diseases such as avian influenza.

    He said that part of what makes the model so useful is its simplicity. Rather than relying on a complicated computer model that takes into account tens or even hundreds of variables, Drake's model has the potential to estimate outbreak size based on four variables: the transmission rate, infectious period, the removal rate and the rate at which the public health response begins to produce diminishing returns.

    Drake points out that during the Singapore outbreak, there was little evidence that the public health response began to produce diminishing returns. He said this finding suggests that although an aggressive public health response is costly, a sluggish one is far worse.

    "An outbreak is very sensitive to how hard you hit it at the very beginning,"Drake said. "The important thing is to gain ground as quickly as possible."

    The study was published in the latest journal of Public Library of Science.

Editor: Liu Dan
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