SEOUL, March 24 (Xinhua) -- A group of Korean researchers announced they
have found how a gene causes the uncontrolled growth of tumor cells in liver
cancer, the Korea Times reported on Monday.
According to the local daily, the research is the first to confirm the role
of a gene called TM4SF5 in liver cancer and could lead to the development of
efficient anti-cancer drugs.
A joint research team, led by Seoul National University Professor Lee
Jung-weon, have already succeeded in producing a chemical compound that can
inhibit the catalystic role of TM4SF5, the daily said.
The paper about the research was published in Journal of Clinical
Investigation on Friday.
"We are now searching for a business partner to conduct clinical research
into liver cancer drugs," the daily quoted the team as saying.
According to the researchers, the TM4SF5, or tetraspanin transmembrane 4
superfamily member 5, has been suspected of being linked to various cancers
since 1998.
The researchers first found that seven of nine patients suffering from
liver cancer had more TM4SF5 in their tissue cells than those of healthy people.
To confirm the relationship between the gene and cancer, they injected mice with
the substance and observed it caused tumor cells to grow.
They said that their finding can allow specific research to go forward on
how to suppress the tumor cells from becoming overly active.